Genetics and Epigenetics of Diabetic Nephropathy.

ABSTRACT:

Background

Diabetic nephropathy (DN) is the most common cause of end-stage renal disease (ESRD) in the USA and worldwide, contributing to significant morbidity and mortality in diabetic patients. A genetic factor for the development of DN is strongly implicated, as only one third of diabetic patients eventually develop kidney disease. Growing evidence also supports an important role of epigenetic modifications in DN.

Summary

Multiple studies have been performed to identify risk genes and loci associated with DN. So far, only several genes and loci have been identified, none of which showed a strong association with DN. Therefore, a better study design with a larger sample size to identify rare variants and a clinically defined patient population to identify genes and loci as

SUBMITTER: Liu R 

PROVIDER: S-EPMC4934801 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature