Biomarkers of Cardiovascular Disease and Mortality Risk in Patients with Advanced CKD.

ABSTRACT:

Background and objectives

The high risk of cardiovascular disease (CVD) and premature death in patients with CKD associates with a plethora of elevated circulating biomarkers that may reflect distinct signaling pathways or simply, are epiphenomena of CKD. We compared the predictive strength of 12 biomarkers analyzed concomitantly in patients with stage 5 CKD.

Design, setting, participants, & measurements

From 1994 to 2014, 543 patients with stage 5 CKD (median age =56 years old; 63% men; 199 patients had CVD) took part in our study on malnutrition, inflammation, and CVD in incident dialysis patients. Circulating levels of albumin, ferritin, high-sensitivity C-reactive protein (hsCRP), IGF-1, IL-6, orosomucoid, troponin T (TnT), TNF, soluble intracellular adhesion molecule, s

SUBMITTER: Sun J 

PROVIDER: S-EPMC4934843 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature