An Ugi Reaction Incorporating a Redox-Neutral Amine C-H Functionalization Step.

ABSTRACT: Pyrrolidine and 1,2,3,4-tetrahydroisoquinoline (THIQ) undergo redox-neutral α-amidation with concurrent N-alkylation upon reaction with aromatic aldehydes and isocyanides. Reactions are promoted by acetic acid and represent a new variant of the Ugi reaction.

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC4934885 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature