Hyperglycemia Induces Cellular Hypoxia through Production of Mitochondrial ROS Followed by Suppression of Aquaporin-1.
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ABSTRACT:
SUBMITTER: Sada K
PROVIDER: S-EPMC4934928 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
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Hyperglycemia Induces Cellular Hypoxia through Production of Mitochondrial ROS Followed by Suppression of Aquaporin-1.
Sada Kiminori K Nishikawa Takeshi T Kukidome Daisuke D Yoshinaga Tomoaki T Kajihara Nobuhiro N Sonoda Kazuhiro K Senokuchi Takafumi T Motoshima Hiroyuki H Matsumura Takeshi T Araki Eiichi E
PloS one 20160706 7
We previously proposed that hyperglycemia-induced mitochondrial reactive oxygen species (mtROS) generation is a key event in the development of diabetic complications. Interestingly, some common aspects exist between hyperglycemia and hypoxia-induced phenomena. Thus, hyperglycemia may induce cellular hypoxia, and this phenomenon may also be involved in the pathogenesis of diabetic complications. In endothelial cells (ECs), cellular hypoxia increased after incubation with high glucose (HG). A sim ...[more]
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2024-09-12 | GSE262717 | GEO