Metabolic fate of poly-(lactic-co-glycolic acid)-based curcumin nanoparticles following oral administration.

ABSTRACT:

Purpose

Curcumin (CUR), the main polyphenol in turmeric, is poorly absorbed and rapidly metabolized following oral administration, which severely curtails its bioavailability. Poly-(lactic-co-glycolic acid)-based CUR nanoparticles (CUR-NP) have recently been suggested to improve CUR bioavailability, but this has not been fully verified. Specifically, no data are available about curcumin glucuronide (CURG), the major metabolite of CUR found in the plasma following oral administration of CUR-NP. Herein, we investigated the absorption and metabolism of CUR-NP and evaluated whether CUR-NP improves CUR bioavailability.

Methods

Following oral administration of CUR-NP in rats, we analyzed the plasma and organ distribution of CUR and its metabolites using high-performance liquid chr

SUBMITTER: Harigae T 

PROVIDER: S-EPMC4935090 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature