Evaluation of a genomic classifier in radical prostatectomy patients with lymph node metastasis.

ABSTRACT:

Objective

To evaluate the performance of the Decipher test in predicting lymph node invasion (LNI) on radical prostatectomy (RP) specimens.

Methods

We identified 1,987 consecutive patients with RP who received the Decipher test between February and August 2015 (contemporary cohort). In the contemporary cohort, only the Decipher score from RP specimens was available for analysis. In addition, we identified a consecutive cohort of patients treated with RP between 2006 and 2012 at the University of California, San Diego, with LNI upon pathologic examination (retrospective cohort). The retrospective cohort yielded seven, 22, and 18 tissue specimens from prostate biopsy, RP, and lymph nodes (LNs) for individual patients, respectively. Univariable and multivariable logistic regres

SUBMITTER: Lee HJ 

PROVIDER: S-EPMC4935177 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature