Efficient synthesis of fluorescent alkynyl C-nucleosides via Sonogashira coupling for the preparation of DNA-based polyfluorophores.

ABSTRACT: A facile and general procedure for the preparation of alkynyl C-nucleosides with varied fluorophores is presented. Sonogashira coupling was used as a key reaction to conjugate the dyes to an easily accessible ethynyl functionalized deoxyribose derivative. The new C-nucleosides were used for the preparation of DNA-based polyfluorophores.

SUBMITTER: Kolmel DK 

PROVIDER: S-EPMC4935563 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature