Prognostic Value of Adipokines in Predicting Cardiovascular Outcome: Explaining the Obesity Paradox.

ABSTRACT:

Objective

To evaluate the cardiovascular (CV) prognostic value of adipokines in a large prospective cohort of patients participating in the Bypass Angioplasty Revascularization Investigation 2 Diabetes trial.

Patients and methods

The effects of the adipokine levels at baseline and change from baseline on the composite outcome (CV death, myocardial infarction, and stroke) were analyzed using unadjusted and fully adjusted Cox models in 2330 patients with type 2 diabetes and coronary artery disease who had participated in the Bypass Angioplasty Revascularization Investigation 2 Diabetes trial (from January 1, 2001, through December 1, 2008).

Results

In a fully adjusted model, baseline leptin and change from baseline leptin were protective for CV events, whereas baseline

SUBMITTER: Wolk R 

PROVIDER: S-EPMC4935584 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature