Inverse Correlation between IL-10 and HIF-1α in Macrophages Infected with Histoplasma capsulatum.

ABSTRACT: Hypoxia-inducible factor (HIF)-1α is a transcription factor that regulates metabolic and immune response genes in the setting of low oxygen tension and inflammation. We investigated the function of HIF-1α in the host response to Histoplasma capsulatum because granulomas induced by this pathogenic fungus develop hypoxic microenvironments during the early adaptive immune response. In this study, we demonstrated that myeloid HIF-1α-deficient mice exhibited elevated fungal burden during the innate immune response (prior to 7 d postinfection) as well as decreased survival in response to a sublethal inoculum of H. capsulatum The absence of myeloid HIF-1α did not alter immune cell recruitment to the lungs of infected animals but was associated with an elevation of the anti-inflammatory cytokine I

SUBMITTER: Fecher RA 

PROVIDER: S-EPMC4935642 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature