Limited genetic and antigenic diversity within parasite isolates used in a live vaccine against Theileria parva.

ABSTRACT: An infection and treatment protocol is used to vaccinate cattle against Theileria parva infection. Due to incomplete cross-protection between different parasite isolates, a mixture of three isolates, termed the Muguga cocktail, is used for vaccination. While vaccination of cattle in some regions provides high levels of protection, some animals are not protected against challenge with buffalo-derived T. parva. Knowledge of the genetic composition of the Muguga cocktail vaccine is required to understand how vaccination is able to protect against field challenge and to identify the potential limitations of the vaccine. The aim of the current study was to determine the extent of genetic and antigenic diversity within the parasite isolates that constitute the Muguga cocktail. High throughput mu

SUBMITTER: Hemmink JD 

PROVIDER: S-EPMC4935670 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature