The CUL3/KLHL3-WNK-SPAK/OSR1 pathway as a target for antihypertensive therapy.

ABSTRACT: Chronic high blood pressure (hypertension) is the most common disease in the Unites States. While several classes of drugs exist to treat it, many patients (up to 10 million Americans) respond poorly to therapy, even when multiple classes are used. Recent evidence suggests that a significant portion of patients will always remain hypertensive despite maximum therapy with the drugs currently available. Therefore, there is a pressing need to develop novel antihypertensive agents. One limitation has been the identification of new targets, a limitation that has been overcome by recent insights into the mechanisms underlying monogenic forms of hypertension. The disease familial hyperkalemic hypertension is caused by mutations in with-no-lysine (WNK) kinases 1 and 4 and in cullin-3 and kelch-lik

SUBMITTER: Ferdaus MZ 

PROVIDER: S-EPMC4935775 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature