Dietary intervention induces flow of changes within biomarkers of lipids, inflammation, liver enzymes, and glycemic control.

ABSTRACT:

Objective

To determine how changes in lipids, liver enzymes, and inflammatory and glycemia markers intercorrelate during prolonged dietary intervention in obese participants with or without type 2 diabetes (T2D).

Methods

We examined the dynamics and intercorrelations among changes in biomarkers during the 2-y Dietary Intervention Randomized Controlled Trial (DIRECT) in 322 participants (including 46 with T2D; 52 y of age, body mass index 31 kg/m(2)) throughout rapid weight loss (0-6 mo) and weight-maintenance/regain (7-24 mo) phases.

Results

The 2-y increase of high-density lipoprotein cholesterol was greater in participants with T2D (+9.41 versus+6.57 mg/dL, P < 0.05), although they tended to have smaller waist circumferences (-2.1 versus -4.0 cm, P = 0.08). In model

SUBMITTER: Golan R 

PROVIDER: S-EPMC4935830 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature