Ustekinumab in Crohn's disease: evidence to date and place in therapy.

ABSTRACT: Crohn's disease (CD) is an inflammatory bowel disease (IBD) with uncertain etiology. Biologic agents have revolutionized the treatment of CD but nonresponders remain a challenge. Ustekinumab is an interleukin 12/23p40 inhibitor that was recently found effective in treating CD. We reviewed the current literature regarding the efficacy of ustekinumab in treating CD and concluded that ustekinumab is a novel, promising and relatively safe agent for the treatment of moderate to severe CD. Additional data from randomized controlled studies and real-life cohorts are pending.

SUBMITTER: Engel T 

PROVIDER: S-EPMC4935835 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature