Green tea catechins are potent anti-oxidants that ameliorate sodium iodate-induced retinal degeneration in rats.

ABSTRACT: Green tea extracts exhibit anti-oxidative and anti-inflammatory actions in different disease conditions. We hypothesized that green tea extract and its catechin constituents ameliorate sodium iodate-induced retinal degeneration in rats by counteracting oxidative stress. In this study, adult Sprague-Dawley rats were intravenously injected with a single dose of sodium iodate. Green tea extract (GTE; Theaphenon-E) or combinations of its catechin constituents, including (-)-epigallocatechin gallate (EGCG), were administered intra-gastrically before injection. Live imaging analysis using confocal scanning laser ophthalmoscopy and spectral-domain optical coherence tomography showed a progressive increase of degenerating profile across the retinal surface and decrease in thickness of outer nuclea

SUBMITTER: Yang Y 

PROVIDER: S-EPMC4935886 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature