Systems view of adipogenesis via novel omics-driven and tissue-specific activity scoring of network functional modules.

ABSTRACT: The investigation of the complex processes involved in cellular differentiation must be based on unbiased, high throughput data processing methods to identify relevant biological pathways. A number of bioinformatics tools are available that can generate lists of pathways ranked by statistical significance (i.e. by p-value), while ideally it would be desirable to functionally score the pathways relative to each other or to other interacting parts of the system or process. We describe a new computational method (Network Activity Score Finder - NASFinder) to identify tissue-specific, omics-determined sub-networks and the connections with their upstream regulator receptors to obtain a systems view of the differentiation of human adipocytes. Adipogenesis of human SBGS pre-adipocyte cells in vit

SUBMITTER: Nassiri I 

PROVIDER: S-EPMC4935943 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature