Unexpected Interfarm Transmission Dynamics during a Highly Pathogenic Avian Influenza Epidemic.

ABSTRACT:

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Next-generation sequencing technology is now being increasingly applied to study the within- and between-host population dynamics of viruses. However, information on avian influenza virus evolution and transmission during a naturally occurring epidemic is still limited. Here, we use deep-sequencing data obtained from clinical samples collected from five industrial holdings and a backyard farm infected during the 2013 highly pathogenic avian influenza (HPAI) H7N7 epidemic in Italy to unravel (i) the epidemic virus population diversity, (ii) the evolution of virus pathogenicity, and (iii) the pathways of viral transmission between different holdings and sheds. We show a high level of genetic diversity of the HPAI H7N7 viruses within a single farm as a consequence of separa

SUBMITTER: Fusaro A 

PROVIDER: S-EPMC4936132 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature