Tetraspanin CD151 Promotes Initial Events in Human Cytomegalovirus Infection.

ABSTRACT:

Unlabelled

Human cytomegalovirus (HCMV), a betaherpesvirus, can cause life-threatening disease in immunocompromised individuals. Viral envelope glycoproteins that mediate binding to and penetration into target cells have been identified previously. In contrast, cellular proteins supporting HCMV during entry are largely unknown. In order to systematically identify host genes affecting initial steps of HCMV infection, a targeted RNA interference screen of 96 cellular genes was performed in endothelial cells by use of a virus strain expressing the full set of known glycoprotein H and L (gH/gL) complexes. The approach yielded five proviral host factors from different protein families and eight antiviral host factors, mostly growth factor receptors. The tetraspanin CD151 was uncovered a

SUBMITTER: Hochdorfer D 

PROVIDER: S-EPMC4936157 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature