Genome-wide search identifies a gene-gene interaction between 20p13 and 2q14 in asthma.

ABSTRACT:

Background

Many studies have attempted to identify gene-gene interactions affecting asthma susceptibility. However, these studies have typically used candidate gene approaches in limiting the genetic search space, and there have been few searches for gene-gene interactions on a genome-wide scale. We aimed to conduct a genome-wide gene-gene interaction study for asthma, using data from the GABRIEL Consortium.

Results

A two-stage study design was used, including a screening analysis (N = 1625 subjects) and a follow-up analysis (N = 5264 subjects). In the screening analysis, all pairwise interactions among 301,547 SNPs were evaluated, encompassing a total of 4.55 × 10(10) interactions. Those with a screening interaction p-value < 10(-5) were evaluated in the follow-up analysis.

SUBMITTER: Murk W 

PROVIDER: S-EPMC4936310 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature