APOE polymorphisms influence longitudinal lipid trends preceding intracerebral hemorrhage.

ABSTRACT:

Objective

We sought to determine whether APOE genotype influences a previously observed decline in serum total cholesterol (TC) and low-density lipoprotein (LDL) levels preceding primary intracerebral hemorrhage (ICH), as a potential demonstration of nonamyloid mechanisms of APOE in ICH risk.

Methods

We performed a single-center retrospective longitudinal analysis using patients with known APOE genotype drawn from an ongoing cohort study of ICH. Serum lipid measurements for TC, triglycerides (TGs), LDL, and high-density lipoprotein (HDL) collected within 2 years before and after index ICH were extracted from electronic medical records. Piecewise linear mixed-effects models were used to compare APOE allele-specific effects on temporal serum lipid trends in ICH. Demographics,

SUBMITTER: Phuah CL 

PROVIDER: S-EPMC4936477 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature