Association between Subclinical Malaria Infection and Inflammatory Host Response in a Pre-Elimination Setting.

ABSTRACT:

Background

Subclinical infections in endemic areas of Southeast Asia sustain malaria transmission. These asymptomatic infections might sustain immunity against clinical malaria and have been considered benign for the host, but if they are associated with chronic low-grade inflammation this could be harmful. We conducted a case-control study to explore the association between subclinical malaria and C-reactive protein (CRP), an established biomarker of inflammation.

Methods

Blood samples from asymptomatic villagers in Pailin, Western Cambodia were tested for malaria by high-volume ultra-sensitive polymerase chain reaction (uPCR) to determine the Plasmodium species. Plasma CRP concentration was measured in 328 individuals with parasitaemia (cases) and compared with: i) the sam

SUBMITTER: Peto TJ 

PROVIDER: S-EPMC4936742 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature