Default Mode Hypoconnectivity Underlies a Sex-Related Autism Spectrum.

ABSTRACT:

Background

Females and males differ significantly in the prevalence and presentation of autism spectrum conditions. One theory of this effect postulates that autistic traits lie on a sex-related continuum in the general population, and autism represents the extreme male end of this spectrum. This theory predicts that any feature of autism in males should 1) be present in autistic females, 2) differentiate between the sexes in the typical population, and 3) correlate with autistic traits. We tested these three predictions for default mode network (DMN) hypoconnectivity during the resting state, one of the most robustly found neurobiological differences in autism.

Methods

We analyzed a primary dataset of adolescents (N = 121, 12-18 years of age) containing a relatively

SUBMITTER: Ypma RJ 

PROVIDER: S-EPMC4936761 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature