Thrombospondin 1 as a novel biological marker of obesity and metabolic syndrome.

ABSTRACT:

Context

Thrombospondin 1 (THBS1 or TSP-1) is an adipose-derived matricellular protein, which has recently been highlighted as a potential mediator of insulin resistance and adipose inflammation in obesity.

Objective

In this study, we aimed to determine the clinical significance of THBS1 as a novel biological marker of visceral obesity, metabolic syndrome, and diabetes.

Methods

The THBS1 mRNA level was quantified with real-time PCR in human adipose tissues obtained from 16 non-obese subjects. The relationships between serum THBS1 level and obesity/diabetes traits as well as the diagnostic components of metabolic syndrome were assessed in 164 normal-weight or overweight/obese subjects (78 males and 86 females; mean age, 50.4; mean BMI, 29.8) with analysis of covariance

SUBMITTER: Matsuo Y 

PROVIDER: S-EPMC4936918 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature