Chromatin Regulators as a Guide for Cancer Treatment Choice.

ABSTRACT: The limited capacity to predict a patient's response to distinct chemotherapeutic agents is a major hurdle in cancer management. The efficiency of a large fraction of current cancer therapeutics (radio- and chemotherapies) is influenced by chromatin structure. Reciprocally, alterations in chromatin organization may affect resistance mechanisms. Here, we explore how the misexpression of chromatin regulators-factors involved in the establishment and maintenance of functional chromatin domains-can inform about the extent of docetaxel response. We exploit Affymetrix and NanoString gene expression data for a set of chromatin regulators generated from breast cancer patient-derived xenograft models and patient samples treated with docetaxel. Random Forest classification reveals specific panels of

SUBMITTER: Gurard-Levin ZA 

PROVIDER: S-EPMC4936925 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature