The Neurogenic Potential of Astrocytes Is Regulated by Inflammatory Signals.

ABSTRACT: Although the adult brain contains neural stem cells (NSCs) that generate new neurons throughout life, these astrocyte-like populations are restricted to two discrete niches. Despite their terminally differentiated phenotype, adult parenchymal astrocytes can re-acquire NSC-like characteristics following injury, and as such, these 'reactive' astrocytes offer an alternative source of cells for central nervous system (CNS) repair following injury or disease. At present, the mechanisms that regulate the potential of different types of astrocytes are poorly understood. We used in vitro and ex vivo astrocytes to identify candidate pathways important for regulation of astrocyte potential. Using in vitro neural progenitor cell (NPC)-derived astrocytes, we found that exposure of more lineage-restric

SUBMITTER: Michelucci A 

PROVIDER: S-EPMC4937102 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature