Genomic Analysis and Comparison of Two Gonorrhea Outbreaks.

ABSTRACT: Gonorrhea is a sexually transmitted disease causing growing concern, with a substantial increase in reported incidence over the past few years in the United Kingdom and rising levels of resistance to a wide range of antibiotics. Understanding its epidemiology is therefore of major biomedical importance, not only on a population scale but also at the level of direct transmission. However, the molecular typing techniques traditionally used for gonorrhea infections do not provide sufficient resolution to investigate such fine-scale patterns. Here we sequenced the genomes of 237 isolates from two local collections of isolates from Sheffield and London, each of which was resolved into a single type using traditional methods. The two data sets were selected to have different epidemiological prop

SUBMITTER: Didelot X 

PROVIDER: S-EPMC4937209 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature