Dysregulated signaling hubs of liver lipid metabolism reveal hepatocellular carcinoma pathogenesis.

ABSTRACT: Hepatocellular carcinoma (HCC) has a high mortality rate and early detection of HCC is crucial for the application of effective treatment strategies. HCC is typically caused by either viral hepatitis infection or by fatty liver disease. To diagnose and treat HCC it is necessary to elucidate the underlying molecular mechanisms. As a major cause for development of HCC is fatty liver disease, we here investigated anomalies in regulation of lipid metabolism in the liver. We applied a tailored network-based approach to identify signaling hubs associated with regulation of this part of metabolism. Using transcriptomics data of HCC patients, we identified significant dysregulated expressions of lipid-regulated genes, across many different lipid metabolic pathways. Our findings, however, show that

SUBMITTER: Lee S 

PROVIDER: S-EPMC4937331 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature