Effects of add-on montelukast on airway hyperresponsiveness in patients with well-controlled asthma - a pilot study.

ABSTRACT:

Objective

Control of airway inflammation is the cornerstone of asthma management. The aim of the present pilot study was to assess the effects of a leukotriene receptor antagonist (LTRA) added to a basic treatment of inhaled corticosteroids (ICS) and long-acting beta-agonist (LABA) on airway hyperresponsiveness, inflammation, and quality of life in well-controlled patients with asthma.

Research design and methods

Seventeen patients (age 18-65, 11 women) with well-controlled asthma presenting airway hyperresponsiveness to mannitol and methacholine challenge were given add-on montelukast on a stable ICS + LABA for 4 weeks. Quality of life and selected parameters of airway inflammation were measured at baseline and at study end. (ClinicalTrials.gov (NCT01725360)).

Results

SUBMITTER: Kononowa N 

PROVIDER: S-EPMC4937661 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature