Independent validation of a mathematical genomic model for survival of glioma patients.

ABSTRACT: An independent cohort study was conducted to validate a mathematical genomic model for survival of glioma patients that was introduced previously. Of the 102 new subjects that were employed in this study, 40 were long-term survivors (survival ≥ 3 years), and 62 were short-term survivors (survival ≤ 1 year). Utilizing the gene expression of 5 genes as captured by mRNA sequencing of primary tumor tissue, obtained from the initial biopsy during the diagnosis, and prior to the administration of any treatment, the model classified correctly all but three of the 102 subjects. More specifically, of the 62 STS (short-term survivors), 61 were classified correctly (sensitivity = 98.4%); and of the 40 LTS (long-term survivors), 38 were classified correctly (specificity = 95.0%). The 5 gene expression

SUBMITTER: Nikas JB 

PROVIDER: S-EPMC4937742 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature