In Utero and Early-Life Exposure to Ambient Air Toxics and Childhood Brain Tumors: A Population-Based Case-Control Study in California, USA.

ABSTRACT:

Background

Little is known about the influence of environmental factors on the etiology of childhood brain tumors.

Objectives

We examined risks for brain tumors in children after prenatal and infant exposure to monitored ambient air toxics.

Methods

We ascertained all cases of medulloblastoma, central nervous system primitive neuroectodermal tumor (PNET), and astrocytoma before 6 years of age diagnosed in 1990-2007 from the California Cancer Registry and selected controls randomly from birth rolls matched by birth year. Exposures to air toxics during pregnancy/infancy for 43 PNET, 34 medulloblastoma, and 106 astrocytoma cases and 30,569 controls living within 5 mi of a monitor were determined. With factor analysis we assessed the correlational structures of 26 probable

SUBMITTER: von Ehrenstein OS 

PROVIDER: S-EPMC4937846 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature