Enhanced identification of synergistic and antagonistic emergent interactions among three or more drugs.

ABSTRACT: Interactions among drugs play a critical role in the killing efficacy of multi-drug treatments. Recent advances in theory and experiment for three-drug interactions enable the search for emergent interactions-ones not predictable from pairwise interactions. Previous work has shown it is easier to detect synergies and antagonisms among pairwise interactions when a rescaling method is applied to the interaction metric. However, no study has carefully examined whether new types of normalization might be needed for emergence. Here, we propose several rescaling methods for enhancing the classification of the higher order drug interactions based on our conceptual framework. To choose the rescaling that best separates synergism, antagonism and additivity, we conducted bacterial growth experiments

SUBMITTER: Tekin E 

PROVIDER: S-EPMC4938094 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature