Mitochondrial Proteostatic Collapse Leads to Hypoxic Injury.

ABSTRACT: Hypoxic injury is a key pathological event in a variety of diseases. Despite the clinical importance of hypoxia, modulation of hypoxic injury mechanisms for therapeutic benefit has not been achieved, suggesting that critical features of hypoxic injury have not been identified or fully understood. Because mitochondria are the main respiratory organelles of the cell, they have been the focus of much research into hypoxic injury. Previous research has focused on mitochondria as effectors of hypoxic injury, primarily in the context of apoptosis activation and calcium regulation; however, little is known about how mitochondria themselves are injured by hypoxia. Maintenance of protein folding is essential for normal mitochondrial function, whereas failure to maintain protein homeostasis (proteos

SUBMITTER: Kaufman DM 

PROVIDER: S-EPMC4938157 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature