Double-Blind Randomized Clinical Trial: Gluten versus Placebo Rechallenge in Patients with Lymphocytic Enteritis and Suspected Celiac Disease.

ABSTRACT:

Background

The role of gluten as a trigger of symptoms in non-coeliac gluten sensitivity has been questioned.

Aim

To demonstrate that gluten is the trigger of symptoms in a subgroup of patients fulfilling the diagnostic criteria for non-coeliac gluten sensitivity (NCGS), which presented with lymphocytic enteritis, positive celiac genetics and negative celiac serology.

Methods

Double-blind randomized clinical trial of gluten vs placebo rechallenge.

Inclusion criteria

>18 years of age, HLA-DQ2/8+, negative coeliac serology and gluten-dependent lymphocytic enteritis, and GI symptoms, with clinical and histological remission at inclusion. Eighteen patients were randomised: 11 gluten (20 g/day) and 7 placebo. Clinical symptoms, quality of life (GIQLI), and presence

SUBMITTER: Rosinach M 

PROVIDER: S-EPMC4938236 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature