Ontology highlight
ABSTRACT:
SUBMITTER: Rengstl B
PROVIDER: S-EPMC4938355 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Rengstl Benjamin B Schmid Frederike F Weiser Christian C Döring Claudia C Heinrich Tim T Warner Kathrin K Becker Petra S A PS Wistinghausen Robin R Kameh-Var Sima S Werling Eva E Billmeier Arne A Seidl Christian C Hartmann Sylvia S Abken Hinrich H Küppers Ralf R Hansmann Martin-Leo ML Newrzela Sebastian S
Oncoimmunology 20160316 6
Hodgkin lymphoma (HL) presents with a unique histologic pattern. Pathognomonic Hodgkin and Reed-Sternberg (HRS) cells usually account for less than 1% of the tumor and are embedded in a reactive infiltrate mainly comprised of CD4(+) T cells. HRS cells induce an immunosuppressive microenvironment and thereby escape antitumor immunity. To investigate the impact of interactions between HRS cells and T cells, we performed long-term co-culture studies that were further translated into a xenograft mod ...[more]