Intrinsic Disorder in Transmembrane Proteins: Roles in Signaling and Topology Prediction.

ABSTRACT: Intrinsically disordered regions (IDRs) are peculiar stretches of amino acids that lack stable conformations in solution. Intrinsic Disorder containing Proteins (IDP) are defined by the presence of at least one large IDR and have been linked to multiple cellular processes including cell signaling, DNA binding and cancer. Here we used computational analyses and publicly available databases to deepen insight into the prevalence and function of IDRs specifically in transmembrane proteins, which are somewhat neglected in most studies. We found that 50% of transmembrane proteins have at least one IDR of 30 amino acids or more. Interestingly, these domains preferentially localize to the cytoplasmic side especially of multi-pass transmembrane proteins, suggesting that disorder prediction could in

SUBMITTER: Burgi J 

PROVIDER: S-EPMC4938508 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature