Quantification of Diaphragm Mechanics in Pompe Disease Using Dynamic 3D MRI.

ABSTRACT:

Background

Diaphragm weakness is the main reason for respiratory dysfunction in patients with Pompe disease, a progressive metabolic myopathy affecting respiratory and limb-girdle muscles. Since respiratory failure is the major cause of death among adult patients, early identification of respiratory muscle involvement is necessary to initiate treatment in time and possibly prevent irreversible damage. In this paper we investigate the suitability of dynamic MR imaging in combination with state-of-the-art image analysis methods to assess respiratory muscle weakness.

Methods

The proposed methodology relies on image registration and lung surface extraction to quantify lung kinematics during breathing. This allows for the extraction of geometry and motion features of the lung tha

SUBMITTER: Mogalle K 

PROVIDER: S-EPMC4938606 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature