Long Term Clinical Prognostic Factors in Relapsing-Remitting Multiple Sclerosis: Insights from a 10-Year Observational Study.

ABSTRACT:

Background

Multiple sclerosis (MS) has a highly heterogenic course making prediction of long term outcome very difficult.

Objective

The objective was to evaluate current and identify additional clinical factors that are linked to long term outcome of relapsing-remitting MS assessed by disability status 10 years after disease onset.

Methods

This observational study included 793 patients with relapsing-remitting MS. Clinical factors hypothesized to influence long term outcome measured by EDSS scores 10 years after disease onset were analysed by Kaplan-Meier-estimates. Multinomial logistic regression models regarding mild (EDSS ≤2.5), moderate (EDSS 3.0-5.5) or severe (EDSS ≥6.0) disability were calculated to correct for confounders.

Results

Secondary progression

SUBMITTER: Bsteh G 

PROVIDER: S-EPMC4938610 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature