Sex Differences in Drosophila Somatic Gene Expression: Variation and Regulation by doublesex.

ABSTRACT: Sex differences in gene expression have been widely studied in Drosophila melanogaster Sex differences vary across strains, but many molecular studies focus on only a single strain, or on genes that show sexually dimorphic expression in many strains. How extensive variability is and whether this variability occurs among genes regulated by sex determination hierarchy terminal transcription factors is unknown. To address these questions, we examine differences in sexually dimorphic gene expression between two strains in Drosophila adult head tissues. We also examine gene expression in doublesex (dsx) mutant strains to determine which sex-differentially expressed genes are regulated by DSX, and the mode by which DSX regulates expression. We find substantial variation in sex-differential expre

SUBMITTER: Arbeitman MN 

PROVIDER: S-EPMC4938635 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature