A rank test for bivariate time-to-event outcomes when one event is a surrogate.

ABSTRACT: In many clinical settings, improving patient survival is of interest but a practical surrogate, such as time to disease progression, is instead used as a clinical trial's primary endpoint. A time-to-first endpoint (e.g., death or disease progression) is commonly analyzed but may not be adequate to summarize patient outcomes if a subsequent event contains important additional information. We consider a surrogate outcome very generally as one correlated with the true endpoint of interest. Settings of interest include those where the surrogate indicates a beneficial outcome so that the usual time-to-first endpoint of death or surrogate event is nonsensical. We present a new two-sample test for bivariate, interval-censored time-to-event data, where one endpoint is a surrogate for the second, l

SUBMITTER: Shaw PA 

PROVIDER: S-EPMC4938716 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature