Ontology highlight
ABSTRACT:
SUBMITTER: Ni J
PROVIDER: S-EPMC4938731 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Nature medicine 20160606 7
Brain metastases represent the greatest clinical challenge in treating HER2-positive breast cancer. We report the development of orthotopic patient-derived xenografts (PDXs) of HER2-expressing breast cancer brain metastases (BCBM), and their use for the identification of targeted combination therapies. Combined inhibition of PI3K and mTOR resulted in durable tumor regressions in three of five PDXs, and therapeutic response was correlated with a reduction in the phosphorylation of 4EBP1, an mTORC ...[more]