DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling.

ABSTRACT:

Rationale

Mitogen-activated protein kinase (MAPK) signaling regulates the growth response of the adult myocardium in response to increased cardiac workload or pathological insults. The dual-specificity phosphatases (DUSPs) are critical effectors, which dephosphorylate the MAPKs to control the basal tone, amplitude, and duration of MAPK signaling.

Objective

To examine DUSP8 as a regulator of MAPK signaling in the heart and its impact on ventricular and cardiac myocyte growth dynamics.

Methods and results

Dusp8 gene-deleted mice and transgenic mice with inducible expression of DUSP8 in the heart were used here to investigate how this MAPK-phosphatase might regulate intracellular signaling and cardiac growth dynamics in vivo. Dusp8 gene-deleted mice were mildly hypercont

SUBMITTER: Liu R 

PROVIDER: S-EPMC4938738 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature