Chromatin variation associated with liver metabolism is mediated by transposable elements.

ABSTRACT:

Background

Functional regulatory regions in eukaryotic genomes are characterized by the disruption of nucleosomes leading to accessible chromatin. The modulation of chromatin accessibility is one of the key mediators of transcriptional regulation, and variation in chromatin accessibility across individuals has been linked to complex traits and disease susceptibility. While mechanisms responsible for chromatin variation across individuals have been investigated, the overwhelming majority of chromatin variation remains unexplained. Furthermore, the processes through which the variation of chromatin accessibility contributes to phenotypic diversity remain poorly understood.

Results

We profiled chromatin accessibility in liver from seven strains of mice with phenotypic diversity

SUBMITTER: Du J 

PROVIDER: S-EPMC4939004 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature