Association of sputum microbiota profiles with severity of community-acquired pneumonia in children.

ABSTRACT:

Background

Competitive interactions among bacteria in the respiratory tract microbiota influence which species can colonize and potentially contribute to pathogenesis of community-acquired pneumonia (CAP). However, understanding of the role of respiratory tract microbiota in the clinical course of pediatric CAP is limited.

Methods

We sought to compare microbiota profiles in induced sputum and nasopharyngeal/oropharyngeal (NP/OP) samples from children and to identify microbiota profiles associated with CAP severity. We used 16S ribosomal RNA sequencing and several measures of microbiota profiles, including principal component analysis (PCA), to describe the respiratory microbiota in 383 children, 6 months to <18 years, hospitalized with CAP. We examined associations between i

SUBMITTER: Pettigrew MM 

PROVIDER: S-EPMC4939047 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature