Amyotrophic lateral sclerosis risk for spinocerebellar ataxia type 2 ATXN2 CAG repeat alleles: a meta-analysis.

ABSTRACT:

Importance

Repeats of CAG in the ataxin 2 gene (ATXN2) in the long-normal range (sometimes referred to as intermediate) have been identified as modifiers of amyotrophic lateral sclerosis (ALS) risk. Prior studies have used thresholding considering various cutoffs for ATXN2 repeat length.

Objective

To calculate association between ATXN2 CAG repeat alleles and increased risk of ALS across multiple ethnic groups.

Data sources

The MEDLINE database was searched for studies published by December 29, 2013, reporting ATXN2 CAG repeat length in patients with ALS and controls.

Study selection

Studies were included if they reported original data on relative risks or odds ratios (ORs) from ALS and control populations for individual ATXN2 alleles. Review articles that repor

SUBMITTER: Neuenschwander AG 

PROVIDER: S-EPMC4939089 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature