Development of a translational model to screen medications for cocaine use disorder I: Choice between cocaine and food in rhesus monkeys.

ABSTRACT:

Background

Homologous cocaine self-administration procedures in laboratory animals and humans may facilitate translational research for medications development to treat cocaine dependence. This study, therefore, sought to establish choice between cocaine and an alternative reinforcer in rhesus monkeys responding under a procedure back-translated from previous human studies and homologous to a human laboratory procedure described in a companion paper.

Methods

Four rhesus monkeys with chronic indwelling intravenous catheters had access to cocaine injections (0, 0.043, 0.14, or 0.43mg/kg/injection) and food (0, 1, 3, or 10 1g banana-flavored food pellets). During daily 5h sessions, a single cocaine dose and a single food-reinforcer magnitude were available in 10 30-min trials.

SUBMITTER: Johnson AR 

PROVIDER: S-EPMC4939093 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature