Inflammatory markers are associated with decreased psychomotor speed in patients with major depressive disorder.

ABSTRACT: Previous data have demonstrated that administration of inflammatory cytokines or their inducers leads to altered basal ganglia function associated with reduced psychomotor speed. Decreased psychomotor speed, referred to clinically as psychomotor retardation, is a cardinal symptom of major depressive disorder (MDD) and has been associated with poor antidepressant treatment response. We therefore examined the association between plasma inflammatory markers and psychomotor speed in ninety-three un-medicated patients with MDD. Psychomotor speed was assessed by a range of neuropsychological tests from purely motor tasks (e.g. movement latency and finger tapping) to those that involved motor activity with increasing cognitive demand and cortical participation (e.g. Trails A and Digit Symbol Subs

SUBMITTER: Goldsmith DR 

PROVIDER: S-EPMC4939278 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature