Pleiotropic effects of 4-hydroxynonenal on oxidative burst and phagocytosis in neutrophils.

ABSTRACT: Metabolic control of cellular function is significant in the context of inflammation-induced metabolic dysregulation in immune cells. Generation of reactive oxygen species (ROS) such as hydrogen peroxide and superoxide are one of the critical events that modulate the immune response in neutrophils. When activated, neutrophil NADPH oxidases consume large quantities of oxygen to rapidly generate ROS, a process that is referred to as the oxidative burst. These ROS are required for the efficient removal of phagocytized cellular debris and pathogens. In chronic inflammatory diseases, neutrophils are exposed to increased levels of oxidants and pro-inflammatory cytokines that can further prime oxidative burst responses and generate lipid oxidation products such as 4-hydroxynonenal (4-HNE). In thi

SUBMITTER: Chacko BK 

PROVIDER: S-EPMC4939321 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature