Neuron-specific enolase as a novel biomarker reflecting tuberculosis activity and treatment response.

ABSTRACT:

Background/aims

It is not clear which tests are indicative of the activity and severity of tuberculosis (TB). This study aimed to investigate the predictive value of neuron-specific enolase (NSE) and to determine the origin of NSE in TB patients.

Methods

A single-center retrospective analysis was conducted on newly diagnosed TB patients between January and December 2010. Patients were categorized into one of two disease groups (focal segmental or extensive) based on chest X-ray. Pre- and post-treatment NSE concentrations were evaluated. To determine the origin of serum NSE concentration, NSE staining was compared with macrophage-specific CD68 staining in lung tissues and with a tissue microarray using immunohistochemistry and immunofluorescence.

Results

A total of 60

SUBMITTER: Nam SJ 

PROVIDER: S-EPMC4939508 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature