Structural Characterization of H1N1 Nucleoprotein-Nucleozin Binding Sites.

ABSTRACT: Influenza viruses are among the most common pathogens that threaten the health of humans and animals worldwide. Various anti-viral therapeutic agents are currently used for treatment and prophylaxis of influenza virus, but the targets of these drugs are easily mutated and result in resistance. Therefore, medications that have broad spectrum coverage are urgently needed to combat with the disease. Since nucleoprotein is regarded as a druggable target due to its conserved sequence and important functions during influenza virus life cycle, numerous studies are focused on this protein in attempts to develop broad-spectrum anti-influenza therapeutics. Recently, a novel small molecule compound, nucleozin, was found to induce large aggregates of nucleoprotein, which in turn caused cessation of vi

SUBMITTER: Pang B 

PROVIDER: S-EPMC4939526 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature