Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice.

ABSTRACT: Identifying preventive targets for Alzheimer's disease is a central challenge of modern medicine. Non-steroidal anti-inflammatory drugs, which inhibit the cyclooxygenase enzymes COX-1 and COX-2, reduce the risk of developing Alzheimer's disease in normal ageing populations. This preventive effect coincides with an extended preclinical phase that spans years to decades before onset of cognitive decline. In the brain, COX-2 is induced in neurons in response to excitatory synaptic activity and in glial cells in response to inflammation. To identify mechanisms underlying prevention of cognitive decline by anti-inflammatory drugs, we first identified an early object memory deficit in APPSwe-PS1ΔE9 mice that preceded previously identified spatial memory deficits in this model. We modelled preven

SUBMITTER: Woodling NS 

PROVIDER: S-EPMC4939702 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature