High Dose Vitamin D Administration in Ventilated Intensive Care Unit Patients: A Pilot Double Blind Randomized Controlled Trial.

ABSTRACT:

Background

There is a high prevalence of vitamin D deficiency in the critically ill patient population. Several intensive care unit studies have demonstrated an association between vitamin D deficiency [25-hydroxyvitamin D (25(OH)D) < 20 ng/mL] and increased hospital length of stay (LOS), readmission rate, sepsis and mortality.

Material and methods

Pilot, double blind randomized control trial conducted on mechanically ventilated adult ICU patients. Subjects were administered either placebo, 50,000 IU vitamin D₃ or 100,000 IU vitamin D₃ daily for 5 consecutive days enterally (total vitamin D₃ dose = 250,000 IU or 500,000 IU, respectively). The primary outcome was plasma 25(OH)D concentration 7 days after oral administration of study drug. Seco

SUBMITTER: Han JE 

PROVIDER: S-EPMC4939707 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature